There are two ways to obtain such compounds. The first method is called the resolution in which the reactants we are starting with are either racemic or achiral. We separate the enantiomers after the production of both enantiomers. This method
Chapter 4 : asymmetric synthesis – analytical methods of determination of the enantiomeric excess
A chiral agent is always necessary to differentiate the enantiomers. The most used methods to determine the ee are the GC with a chiral stationnary phase, HPLC with a chiral stationnary phase, NMR with chiral lanthanides. Gazeous chromatography The stationnary
Chapter 3 : asymmetric synthesis – stereoisomery
Editor’s note: It is a good exercise to determine the configuration (R or S) of each chiral centre presented in this course. Some molecules have the same composition in terms of atoms but differ by their placement. Those molecules are called conformers (of
Chapter 2 : chemical kinetics – catalysis
Homogeneous catalysis In some conditions, a same reaction A → B can lead to two different kinetics depending on the composition of the solution in which it is. One species C, apparently not intervening in the reaction as it is
Chapter 1: chemical kinetics – relaxation to the equilibrium
Reaction of order 1 Considering an equilibrium between two species A and B We can study the return to the equilibrium (or relaxation) after a sudden modification of the conditions such as a jump of temperature or of pressure, or